教育背景
2012.09 – 2017.07,清华大学机械工程系,博士
2015.10 – 2016.11,宾夕法尼亚大学生物工程系,联培博
2008.09 – 2012.07,清华大学机械工程系,学士
工作履历
2020.12 – 至今,清华大学机械工程系,助理教授
2017.08 – 2020.12,帝国理工学院材料系,博士后
科研工作
关键词:生物制造、生物三维打印、生物墨水、体外生命系统工程、组织工程、生物材料。
体外命系统工程是以工程化技术手段构建体外有生命的生物学模型的一门交叉学科,它在生命科学基础研究、疾病诊断/治疗、组织修复/再生等领域,均具有巨大的应用潜力。生物制造是体外生命系统的重要实现手段,特别是以含活细胞生物材料为操控对象的增材制造、模块化组装等技术的发展,以“自下而上”的思想,为构建复杂组织/器官模型提供了更多机会和可能。近年来课题小组在相关领域开展了系统研究,已在Sciences Advances, Advanced Materials, Materials Today等期刊发表系列高质量研究论文,论文篇均IF>10,篇均引用>100次(Google scholar),其中第一作者ESI高被引论文4篇。出版生物3D打印英文专著1本(独作,Springer出版社),授权国家发明专利2项(第一发明人)。
目前的研究方向包括:
1. 生物制造使能技术创新;
2. 基于细胞动态微环境的材料创新;
3. 面向再生医学与体外生命系统工程的应用创新。
课题组每年招收博士生,欢迎优秀的推免本科生及硕士生联系咨询。
课题组常年招聘博士后及科研助理,欢迎具有相关学科背景及研究兴趣的青年人才加盟。
论文与专利
Google Scholar: https://scholar.google.com/citations?user=06FvzqQAAAAJ&hl=en
专著:
1. L. Ouyang, Study on Microextrusion-based 3D Bioprinting and Bioink Crosslinking Mechanisms (Springer, Singapore, 2019). ISBN 978-981-13-9455-3.
代表性论文(+共同一作,*通讯作者):
1. L. Ouyang*, Pushing the Rheological and Mechanical Boundaries of Extrusion-based 3D Bioprinting. Trends in Biotechnology, 10.1016/j.tibtech.2022.01.001 (2022).
2. L. Ouyang*, J.P. Wojciechowski, J. Tang, Y. Guo, M.M. Stevens*, Tunable Microgel-Templated Porogel (MTP) Bioink for 3D Bioprinting Applications, Advanced Healthcare Materials, 10.1002/adhm.202200027 (2022).
3. Z. Fu, L. Ouyang*, R. Xu, Y. Yang, W. Sun*, Responsive Biomaterials for 3D Bioprinting: A Review. Materials Today, 10.1016/j.mattod.2022.01.001 (2022).
4. C. Li+, L. Ouyang+, J.P.K. Armstrong*, M.M. Stevens*, Advances in the Fabrication of Biomaterials for Gradient Tissue Engineering. Trends in Biotechnology, 39, 150-164 (2021).
5. L. Ouyang, J.P.K. Armstrong, Y. Lin, J.P. Wojciechowski, C. Lee-Reeves, D. Hachin, K. Zhou, J.A. Burdick, M.M. Stevens*, Expanding and Optimizing 3D Bioprinting Capabilities using Complementary Network Bioinks. Science Advances, 6, eabc5529 (2020).
6. L. Ouyang, J.P.K. Armstrong, M. Salmeron‐Sanchez, M.M. Stevens*, Assembling Living Building Blocks to Engineer Complex Tissues. Advanced Functional Materials 30, 1909009 (2020).
7. L. Ouyang, J.P.K. Armstrong, Q. Chen, Y. Lin, M.M. Stevens*, Void‐Free 3D Bioprinting for In Situ Endothelialization and Microfluidic Perfusion. Advanced Functional Materials 30, 1908349 (2020).
8. L. Ouyang, J.A. Burdick, W. Sun*, Facile Biofabrication of Heterogeneous Multilayer Tubular Hydrogels by Fast Diffusion-induced Gelation. ACS Applied Materials & Interfaces 10, 12424-12430 (2018).
9. L. Ouyang, C.B. Highley, W. Sun, J.A. Burdick*, A Generalizable Strategy for The 3D Bioprinting of Hydrogels From Nonviscous Photo‐Crosslinkable Inks. Advanced Materials 29, 1604983 (2017).
10. L. Ouyang+, C.B. Highley+, C.B. Rodell, W. Sun, J.A. Burdick*, 3D Printing of Shear-thinning Hyaluronic Acid Hydrogels with Secondary Cross-linking. ACS Biomaterials Science & Engineering 2, 1743-1751 (2016).
11. L. Ouyang, R. Yao*, Y. Zhao, W. Sun, Effect of Bioink Properties on Printability and Cell Viability for 3D Bioplotting of Embryonic Stem Cells. Biofabrication 8, 035020 (2016).
12. L. Ouyang+, R. Yao+, S. Mao, X. Chen, J. Na, W. Sun*, Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation. Biofabrication 7, 044101 (2015).
13. L. Ouyang+, R. Yao+, X. Chen+, J. Na*, W. Sun*, 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions. Biofabrication 7, 015010 (2015).
授权专利:
1. 欧阳礼亮; 孙伟; 赵雨; 一种异质多层结构的水凝胶及其制备方法, 2020-5-22,中国, ZL201710499076.7.
2. 欧阳礼亮; 孙伟; 赵雨; 一种中空管结构的多层水凝胶及其制备方法与应用, 2020-4-28, 中国, ZL201710530224.7.
奖励与荣誉
SBF New Investigator Award 2021, ISBF
Outstanding Reviewers Award 2019, 2018, IOP
Top Cited Author Award 2018 (China), IOP
GE Foundation TECH Award 2016, First Place Award.
清华大学优秀博士论文,2017年
清华大学优秀博士毕业生,2017年
国家奖学金,2016年
清华大学优良毕业生,2012年