题目:体外生命系统工程系列讲座(第七期):In vitro Engineering Living System Lecture Series (No. 7)

时间:8月4日(周五)15:00

主持人: 孙伟

地 点: 李兆基科技大楼A404

主 办: 清华大学机械工程系

领域:生物医学工程、材料科学与工程

报告题目1:Finding Bacteria: The Bad, The Good, and The Better

报告人1:Prof. MinJun Kim

个人简介1:Dr. MinJun Kim is presently the Robert C. Womack Endowed Chair Professor of Engineering at the Department of Mechanical Engineering, Southern Methodist University. He received his B.S. and M.S. degrees irMechanical Engineering from Yonsei University in Korea and Texas A&M University, respectively. Dr. Kim completed his Ph.D. degree in Engineering at Brown University, where he held the prestigious Simon Ostrach FellowshipFollowing his graduate studies, Dr. Kim was a postdoctoral research fellow at the Rowland Institute in Harvard University. He joined Drexel University in 2006 as Assistant Professor and was later promoted to Professor of Mechanical Engineering and Mechanics. Dr. Kim has been exploring biological transport phenomena including cellular/molecular mechanics and engineering in novel nano/microscale architectures to produce new types of nanobiotechology, such as nanopore technology and nano/micro robotics. His notable awards include the National Science Foundation CAREER Award (2008), Drexel Career Development Award (2008), Human Frontie Science Program Young Investigator Award (2009), Army Research Office Young Investigator Award (2010), Alexander von Humboldt Fellowship (2011), KOFST Brain Pool Fellowship (2013 & 2015), Bionic Engineerind Outstanding Contribution Award (2013), Louis & Bessie Stein Fellowship (2008 & 2014), ISBE Fellow (2014) ASME Fellow(2014),Top10 Netexplo Award (2016), KSEA & KOFST Engineer of the Year Award (2016), EEE Senior Member (2017), Gerald J.Ford Research Fellowship (2018), and Protégé of the Academy of Medicine Engineering and Science of Texas (2019).

报告摘要1:There are over 10,000 species of bacteria have been identified thus far and it is estimated that there are still millions more yet to be discovered. Of the known species, around 20% are known to be ‘bad’ for humans; that is, they can be infectious or harmful to the environment. For example, certain spices of Escherichia coli and Salmonella are well known for their ability to infect our digestive system. On the other hand, there are many bacteria that are ‘good’ for humans. Take for example, Lactobacillus bacteria which are used to ferment dairy products (e.g. cheese and yogurt), Pseudomonas that are used in bioremediation, and Bifidobacterium that live in our guts and protect against inflammation and infection. Still, while they have been exploited for their beneficial natural functions, better uses for bacteria can be found. One example of finding better uses of bacteria is the use of their organelles, specifically their flagella, for engineering applications. Bacterial flagella are helical nantotubes that bacteria rotate in order to move. These naturally occurring nanostructures have many unique properties that can be manipulated for numerous applications. Since the 1960s it’s been known that self-assembly of flagella can be manipulated in vitro, such that flagella can be ‘grown’ to lengths 10 times their normal length. Utilizing this knowledge, flagella have been used as biotemplates for inorganic nanotubes, including silver, titanium, and silica. Using flagella as nanotemplates versus fabrication of purely inorganic nanotubes has a number of advantages including lower cost, faster fabrication times, and are more environmentally friendly. Once fabricated, these biotemplated structures could be used in electrodes, dye sensitized solar cells, or as hydrophobic/hydrophilic coatings. In addition to biotemplates, bacterial flagella by themselves can be used for the propulsion of abiotic swimming microrobots. Mimicking how real bacteria swim, using a low power rotating magnetic field to rotate flagellated magnetic microparticles, a possible tool for in vivo applications, such as targeted drug delivery and minimally invasive surgery could be achieved. Another application of flagella can be derived from their hollow structure; bacterial flagella have a pore that is approximately two nanometers in diameter. The porous nanostructure of flagella has the potential to be utilized in a novel filtration device. Specifically, if templated flagella were imbedded in a solid polymer resin and then sectioned, a nanoporous membrane could easily be fabricated. Furthermore, by functionalizing the pores, filtration of individual analytes could be realized. This filter could be used for the high-throughput separation of serum cytokines, or other low abundance chemicals, that act as biological biomarkers.

报告题目2:Development of Multiscale Porous Metal Support For Thin-Film Solid Oxide Fuel Cells

报告人2:Prof. Suk Won Cha

个人简介2:Since 2005, Prof. Suk Won Cha has been an assistant, associate and full professor in the Department of Mechanical Engineering at Seoul National University. He served as the Associate Dean at the College of Engineering from 2013 to 2015 and the Associate Dean of Office of International Affairs at Seoul National University from 2019 to 2021. Currently, Prof. Cha serves as the President of Advanced Institute of Convergence Technology, a joint institute founded by Seoul National University and Gyeonggi Province of Korea.

Prof. Cha studied engineering at Seoul National University for B.S. degree and at Stanford University for M.S. and Ph.D. degree. For the past decades, Prof. Cha investigated advanced electrochemical cells from materials to system level. He pioneered innovative vacuum fabrication process for electrolyte/electrode materials, optimal energy management strategy of such systems, publishing more than two hundred papers – including covers and frontispiece - in relevant journals such as Journal of Materials Chemistry, Advanced Energy Materials, Applied Energy, Journal of Power Sources, CIRP Annals-Manufacturing Technology, IEEE Transactions on Control Systems Technology and so on. Also, Prof. Cha is well-recognized as a co-author of “Fuel Cell Fundamentals (Wiley and Sons)” - the world-wide bestseller in fuel cells research.

Prof. Cha served as an organizer, committee and board member of numerous conferences such as World Chemistry Congress (IUPAC), and International Electric Vehicle Symposium and Exhibition, Asian Solid Oxide Fuel Cells Symposium and Exhibition, Thin Films Meetings and so on. In addition, he was a longtime organizing chair of International Conference on Precision Engineering and Sustainable Manufacturing. Currently, Prof. Cha serves as a Vice President of Thin Films Society and also the Editor-In-Chief of International Journal of Precision Engineering and Manufacturing – Green Technology.

As a recognition of his contribution to academic society, Prof. Cha is the recipient of several awards including Fuel Cells Research Award from The Korean Electrochemical Society, Academic Excellence Award from The Korean Society of Automotive Engineers, Highly Commended Paper of the Year from International Journal of Precision Engineering and Manufacturing – Green Technology and Springer Award for Most Cited Author of the Year from International Journal of Automotive Technology.

报告摘要2:Despite global efforts to reduce carbon dioxide emissions, the average global temperature continues to rise. Interest in renewable energy to replace fossil fuels is increasing, and solid oxide fuel cells are spotlighted as a promising alternative. In this study, a thin film solid oxide fuel cell was fabricated using inexpensive and highly productive metal support. In order to directly apply the thin film process to the metal support, a process for controlling the pores of the metal support was developed. Through the developed process, a metal-supported thin-film solid oxide fuel cell with high performance even at low temperatures was fabricated.